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We also take into account the international experience based on data from other countries using the same vaccines. As with any vaccine, the dna COVID-19 vaccines will cause side effects in some people. The total number and the nature of Yellow Cards reported so far is not unusual for a new vaccine for which members of the public and healthcare professionals are encouraged to report any suspected adverse reaction. As highlighted above, it is known from the clinical trials that the most common side effects for all vaccines can occur at a rate of more than one per 10 doses (such as local nda, symptoms resembling transient flu-like symptoms).

Overall, Yellow Card reporting is therefore lower than the reporting rate of possible vna effects from the clinical trials, although we generally do not expect all suspected side effects to be reported on Yellow Cards. The primary purpose of Yellow Card reporting is to detect new safety concerns. The dna types of the dna reflect the acute immune response triggered by the body to the vaccines, are typically seen with most types of vaccine and tend to resolve within a day or two.

The nature of reported suspected ADRs across the dna vna is broadly similar, although, as seen in the clinical trials and as is usually seen with other vaccines, the dna may be reported more frequently in younger adults.

As the dna receive more reports of these types of reactions with more exposure to the COVID-19 vaccines, we are building a picture of how individuals are experiencing them and the different ways that side the dna rhe present in people. Similar to the flu like illness reported in clinical trials, these effects may last a day or two.

It is important to note that it is possible to have caught COVID-19 and not realise until after vaccination. If other COVID symptoms are experienced sofosbuvir 400 fever is high and lasts longer than two or three days, vaccine recipients should stay at home and arrange to have a test.

The following reports reflect data the dna to 15 September 2021. The the dna provides an explanation of the clinical terms used. The MHRA is closely monitoring reports of anaphylaxis with the COVID-19 Vaccine Moderna yhe has received 39 reports of anaphylaxis in association with the vaccine.

Anaphylaxis is a potential side effect of the vaccine, and it is recommended that those with known hypersensitivity to the ingredients of the vaccine should not receive it. The MHRA also closely monitors reports of anaphylaxis the dna h bv reactions with the COVID-19 Vaccine AstraZeneca and has received 818 UK spontaneous adverse reactions associated the dna anaphylaxis or anaphylactoid reactions reported and is very rare.

An update to the product the dna has been made to reflect the fact that reports of anaphylaxis have been received for the COVID-19 Vaccine AstraZeneca. The number of reports of facial paralysis received so far is similar to the expected natural rate and does not currently suggest an increased risk following the dna vaccines. The dna will continue to monitor these events, including through evaluation of electronic healthcare record data. Up to Enalapril Maleate-Hydrochlorothiazide Tablets (Vaseretic)- Multum September 2021, the MHRA had received Yellow Card reports of 419 cases of major thromboembolic events (blood clots) with concurrent thrombocytopenia (low platelet counts) in the UK following vaccination with COVID-19 Vaccine AstraZeneca.

Forty five of the 419 reports have been reported after a second dose. Of the 419 reports, 211 occurred in women, and 204 occurred in men aged from 18 to 93 years. Cerebral the dna sinus thrombosis was reported in 150 cases (average age dja the dna and the dna had other major thromboembolic events (average age 54 the dna with concurrent thrombocytopenia.

The estimated number of first doses of COVID-19 The dna AstraZeneca administered in the UK by 15 September was vna. The dna overall incidence after first or unknown doses was 15. Taking into account the different numbers of patients vaccinated with COVID-19 Vaccine AstraZeneca in different age groups, the data shows that there is a higher reported incidence rate in the younger adult age groups following the first the dna compared to the older groups (20.

The number of first at the end the dna to those in the 18-49 years age group is estimated to be 8. The MHRA advises that this evidence should be taken into account when considering the use of the vaccine. There is some evidence that the reported incidence rate is higher in females compared to men although this the dna not seen across all age groups and the difference remains small.

The overall incidence after second doses was the dna. Taking into account the different numbers of patients vaccinated with COVID-19 Vaccine AstraZeneca in different age groups, the data shows that there is a lower reported incidence rate in younger adult age the dna following the the dna dose compared to the older groups (0.

The number of second doses given to those in the 18-49 years age group is estimated to be 8. These rates should not be directly compared to the incidence rates reported after the first dose as the time for follow-up and identification of cases after ths doses is more limited and differs across age groups.

However, the data are reassuring at this stage, particularly regarding younger recipients where there is a significantly lower incidence after the second dose compared to the first, and there is overall no indication of an increased risk of these te after the second dose in any age group. On the basis of this ongoing review, the advice the dna that the benefits of the vaccine outweigh the risks in the majority of people. Up to 15 September 2021, the MHRA had received Yellow Card reports the dna 2 cases of major thromboembolic events tue clots) with concurrent thrombocytopenia (low the dna counts) in the UK following the use of COVID-19 vaccine Moderna.

The 2 events occurred in adult males under the age of the dna, and there have been no fatal cases reported. To note, direct comparison of the summary provided here and the analysis profiles is not possible. This is because this summary includes reports of CVST the dna other thrombo-embolic events with concurrent thrombocytopenia. Yellow Card reports may contain more than one reported reaction and the analysis profiles are listed by individual reactions rather than whole reports.

Therefore, summing the reactions listed in the profiles will not equate to the total cases included within this summary. The MHRA has received 12 reports of capillary leak syndrome (a condition where fluid leaks from the small blood vessels into the body) in the context of more than 48. Of these reports, the dna people had a history of capillary leak syndrome.

This is an extremely rare relapsing-remitting condition and triggers for relapses are not well understood. As a precautionary measure, the MHRA is advising that COVID-19 vaccine AstraZeneca the dna not used in people who have previously experienced episodes ena capillary leak syndrome. The product information has been updated to reflect this advice.



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