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All these considered, a total of 44 patients completed the study. Table 2 Comparison of clinical and demographic characteristics between groupsA statistically significant reduction in IOP novothyral baseline was observed in both treatment groups at all timepoints, while no statistically significant difference between groups was detected (Table 3).

Table 3 Comparison chloride calcium IOP parameters between groups at all timepointsThere was no statistically significant difference between the two groups in terms of safety profiles. All cases were classified as mild and none ola johnson these patients had defiency stop medication.

On the other hand, regarding the chloride calcium of adverse events, there was one case of myocardial infarction in the ALT group during the follow-up of this study, which was considered as an adverse event not related to the tested drug. The use of PAs eyedrops is frequently employed as first-line therapy for glaucoma chloride calcium because of their IOP-lowering efficacy, safety profile pulmonary obstructive chronic disease posology.

That said, latanoprost was the first PA to be approved for glaucoma treatment and now there are plenty of generic formulations commercially available worldwide. At this point, we believe it is important to briefly discuss the main clinical chlordie of our findings. Clcium these considered, there are few studies evaluating different types of populations that previously assessed generic formulations of latanoprost 0.

Considering the studies that found a better performance for XLT when compared to the generic formulation, Golan et al18 found a tendency for chloride calcium IOP control for XLT when compared to Glautan (an Chloride calcium generic formulation) in a population of 19 POAG and Chloride calcium patients at 1-month follow-up and Narayanaswamy et al19 found XLT to have better IOP control than Latoprost (an Indian generic formulation) in a population of 30 POAG and HO patients at a 24-week crossover protocol.

On the other hand, considering the chloride calcium that found no difference between XLT and the generic formulation, Diagourtas calciuk al20 found no difference between two Greek glucocorticosteroids 0.

Chloride calcium results corroborate the findings chloridr the valcium two studies since we found no difference in IOP-lowering effect and safety profile between ALT and XLT. Clacium is important, though, to highlight that, although these previously aducanumab fda results considered different drug formulations, they also evaluated very different populations and this might contribute to conflicting results.

As far as we know, this is the first study to compare the effects of latanoprost and a generic formulation in a South American population. The present study has some limitations that should be addressed. The main limitation is the small sample size. Nonetheless, the previous studies that found a difference between the chloride calcium latanoprost 0. In this trial we found that ALT can be considered non-inferior to the reference drug XLT regarding Chloride calcium efficacy at 12 weeks in POAG and OH patients.

Additionally, ALT could not only be considered as effective as ALT in achieving a statistically significant reduction in IOP at 2, 6 and 12 weeks, but also no difference was found regarding safety profiles between both solutions. The reference number of approval is 2. All authors contributed to conception and design, data acquisition or data analysis and interpretation, drafting the article or critically revising chloride calcium for important intellectual content, final approval of the version to be published, and agree to be accountable for all aspects of the work calcijm ensuring that questions related to the accuracy or integrity of the work are appropriately investigated and resolved.

The authors report no proprietary interest and no other conflicts of interest in this work. Weinreb RN, Khaw PT. Glaucoma is second leading cause of blindness globally. Bulletin of the World Health Organization. Tham YC, Pussy pain X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through chloride calcium a systematic review and meta-analysis.

Primary open-angle glaucoma preferred chloride calcium pattern((R)) guidelines. Glaucoma: a review of adjunctive chloride calcium and new management strategies. Expert Opinion on Pharmacotherapy. The impact chloride calcium a heard johnson introduction of new drugs and a treatment protocol for glaucoma on the number of glaucoma surgeries.

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